Medical Research Council - London Institute of Medical Sciences

In 2017 we celebrated five years of bringing you beautiful imagery from biomedical science

Inflammation Control
27 April 2012

Inflammation Control

Inflammation is our body’s first line of defence against infection or trauma. At the first sign of trouble immune cells (like the macrophage here visualised using computer-graphics) send out protein messengers to muster cellular troops to deal with the assault. Switching on the inflammatory response prevents overwhelming infection. But switching it off is critical too, since too much inflammation can damage body tissue. When an invader is detected a group of proteins (marked here in red) co-ordinate the crucial call to the cellular troops. Researchers have discovered that a protein called p62 (green) rapidly silences the alarm bell by labelling the relevant proteins for destruction in a cellular ‘bin-liner’ (visualised in yellow). Understanding how the inflammatory system works will help researchers find ways to prevent it from inflicting damage on the body’s own cells, as occurs in certain autoimmune disorders.

Written by Caroline Cross

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More