Medical Research Council - London Institute of Medical Sciences

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04 September 2015

Breaking Down Brains

The relationships between the different cellular objects which make up neural tissue in a human brain are largely unknown. To address this researchers have started to use electron microscopy as a technique to study neural tissue at nanometre resolution, managing to reconstruct a complete, but small, portion of a mouse neocortex – the part of a mammalian brain concerned with sensory information and conscious thought. Thousands of brain slices, each around 1 mm2, were studied and used to reconstruct a volume of brain tissue (as shown), which can be expanded to show all the cellular and sub-cellular components, such as axons and glia. More studies like this will be used to create an online database of information, providing insight into how the neural network is related to the physical properties of brain tissue, identifying any patterns which may correlate to psychological or development disorders.

Written by Helen Thomas

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