Medical Research Council - London Institute of Medical Sciences

Now in our 7th year of bringing you beautiful imagery from biomedical science every day

Micro-nuclear Disaster
20 January 2016

Micro-nuclear Disaster

In vitro fertilisation, or IVF, is the last hope for infertile couples hoping to have children, but the technique is fraught with complications. Many embryos are rejected, as they develop defects; for example, mosaic embryos contain some cells with abnormal numbers of chromosomes, a condition known as aneuploidy. By observing developing mouse embryos, like the one pictured, researchers have recently uncovered a possible explanation for this problem. When cells multiply, they duplicate their genetic material, then carefully distribute copies of each chromosome into their daughter cells. Any mistakes can cause the formation of micronuclei, structures containing isolated chromosomes, which are not correctly allocated during subsequent cell divisions. In developing mice, and most likely in humans too, this leads to embryos with cells containing different numbers of chromosomes. Understanding how these mosaics arise may help ensure more embryos develop without defects, hopefully increasing the chance of success for IVF patients.

Written by Emmanuelle Briolat

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at with translations by the University of Valencia.