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Gut Feeling
13 November 2016

Gut Feeling

Some scientists call it our ‘second brain’. It comprises around 100 million nerve cells, ensures we get all the nourishment we need, and even affects our mood. This ‘brain’ is actually a network of nerves called the enteric nervous system, which controls our gut. Loss of these nerves results in a group of diseases called enteric neuropathies. The consequences on the body are severe: poor nutrition, pain, nausea, vomiting, diarrhoea, and constipation. Researchers now use mice to investigate the potential of stem cells in replacing these lost nerves. Stem cells, called enteric neural crest cells (ENCCs), were implanted into the guts of normal mice (pictured) and mice lacking gut nerves. ENCCs (green/yellow) integrated into the guts of both types of mice, did not cause tumours, and developed into nerves that appeared functional when stimulated electrically. This is the first step towards future therapies in humans.

Written by Lux Fatimathas

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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