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World Rabies Day Rabid Journeys
28 September 2016

Rabid Journeys

A bite from a rabid animal plunges the rabies virus straight into enemy territory, facing a long and arduous journey to its ultimate target. It travels from the bite mark along peripheral nerves to finally reach the brain. Researchers modelled this using microfluidic devices – special constructs where peripheral nerve cells could grow with their cell bodies (bottom) and neurite projections (top) in separate compartments, joined only by tiny channels (middle) through which neurites could pass. Adding the virus to the neurite compartment, alongside chemicals to block different proteins, revealed that viruses enter cells through ‘pits’ in their membrane coated with the protein clathrin. These pits pinch off into packages that are transported to the cell body using another protein, dynamin. Crucially, efficient infection depends on these packages reaching the cell body. These insights untangle how rabies infection takes hold.

Today is World Rabies Day

Written by Lux Fatimathas

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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