Fibroblast cells – like this one here – are inconspicuous but vitally important cells. They make up most of the biological ‘glue’ that holds our cells and organs together, known as connective tissue, and spring into action wherever they’re needed to heal wounds and repair damage. This cell is stained with a fluorescent dye highlighting a molecule called tissue factor, which triggers a cascade of chemical reactions that kick-start blood clot formation – the first step in the wound healing process. Although blood clots are vital for patching up broken bodies they can cause problems if they form inside blood vessels. Dislodged blood clots get stuck in vital arteries, blocking blood flow and causing heart attacks or strokes. Because of their key role in blood clot formation, fibroblasts and the molecules they make are prime targets for scientists seeking new clot-busting therapies, with the potential for saving thousands of lives every year.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.