Medical Research Council - London Institute of Medical Sciences

BPoD is 5

In 2017 we celebrate five years of bringing you beautiful imagery from biomedical science

World No Tobacco Day Signal Interference
31 May 2017

Signal Interference

Over 30% of human cancers involve mutations in the Ras family of genes, so inhibiting their activity is a key goal for cancer biologists. Ras genes encode crucial signalling proteins, involved in many important processes, from metabolism to cell proliferation. Although Ras proteins have proven difficult to target directly, identifying the molecules they interact with could provide an alternative solution, and recent research suggests that another signalling protein, known as RIOK1, could be a promising candidate for action. This protein is known to be over-expressed in some cancer types, while tumour growth was reduced after breast, colorectal and lung cancer cells (pictured, with nuclei in blue) were genetically-modified to prevent production of RIOK1. As RIOK1 belongs to a family of proteins which are already targeted by some cancer treatments, researchers believe that designing specific inhibitors to block the function of RIOK1 could be possible, suggesting a potential therapeutic solution.

Today is World No Tobacco Day

Written by Emmanuelle Briolat

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More