Medical Research Council - London Institute of Medical Sciences

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No Default Sex
02 September 2017

No Default Sex

Male and female embryos start out roughly the same, but as development progresses, the tissues that will ultimately become sperm- or egg-producing structures are either retained or eliminated, depending on sex. It was thought that genes present only on the Y chromosome controlled the development of male-specific structures, and that the lack of a Y chromosome resulted in female-specific structures. In other words, that male development was an active process and female development the default. It is now clear, however, that the development of female sex organs is active too. Researchers have discovered a factor produced in female mice necessary for the elimination of male-specific tissues. The mutant embryo (bottom) lacks this factor and thus retains both female and male precursor tissues (pink and blue). This new discovery should help to inform studies into both intersex development and certain reproductive problems.

Written by Ruth Williams

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