Medical Research Council - London Institute of Medical Sciences

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Stemming Stem Cells
02 March 2018

Stemming Stem Cells

Stem cells are essential for complex life. These immortal cells – found in embryos and adults – keep on dividing long after other cells have stopped, making more of themselves and generating specialised cells that make up the tissues of the body. But while it’s vital that stem cells can keep on multiplying, it’s also important that they don’t grow out of control and become a cancerous tumour. To find out how stem cells maintain this precarious balance, researchers are studying these snake-like sex organs (gonads) in tiny nematode worms called C. elegans. The brightly coloured patches are two proteins – SYGL-1 (pink) and LST-1 (orange) – which help stem cells maintain their immortal character. By limiting the area in which these proteins are active, the worms ensure that the pool of stem cells stays small. Maybe similar mechanisms are at work in our own bodies to keep our unruly stem cells in check?

Written by Kat Arney

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