Medical Research Council - London Institute of Medical Sciences

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Exercise Pill

Molecule identified that recapitulates the benefits of exercise on nerve cell regeneration

15 May 2019

Exercise Pill

Rodents that engage in physical activity – running on a wheel, exploring their environment, and so on – have been found to recover better after spinal injuries than their sedentary counterparts. And now scientists are beginning to uncover the molecular nuts and bolts that explain why. Exercise, it turns out, modifies the chromatin [DNA’s packaging material] of nerve cells (red). Specifically, it increases the acetylation of histones [chromatin proteins] and this, in turn, increases the cells’ regenerative capacity. Excitingly, scientists have also discovered a small molecule that can recapitulate the effects of exercise, increasing histone acetylation (green/yellow) and regeneration capacity of nerves and improving recovery after spinal injury. While this molecule may lead to the development of a drug that promotes recovery and rehabilitation after nerve damage, such a drug is unlikely to replace the additional health benefits of exercise, so don’t go cancelling your gym memberships just yet.

Written by Ruth Williams

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