Medical Research Council - London Institute of Medical Sciences

Now in our 9th year of bringing you beautiful imagery from biomedical science every day

Consumed by Cancer

Muscle-wasting in cancer - cachexia – is promoted by a tumour cell protein helping them grow

11 November 2020

Consumed by Cancer

In the late stages of cancer, patients sometimes suffer from extreme muscle deterioration and weight loss– a condition known as cachexia. But, whether this tissue degradation is advantageous to the cancer or merely a consequence of disease was not clear. Studies of tumour growth in fruit flies now suggest that indeed cancers dismantle muscle to make themselves stronger. The development of certain tumours in the flies caused healthy muscle (left) to waste away (right), which fuelled both tumour growth and further muscle destruction. The tumours were found to produce a transporter protein that enabled them to suck up amino acids – protein building blocks – from the deteriorating muscle, and use them for their own growth. Researchers have also identified a compound that blocks the transporter and that, when fed to flies, inhibited tumour growth and prevented cachexia. The hope is that such a compound may have anticancer effects in humans too.

Read more about this research at the MRC LMS here

Written by Ruth Williams

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at with translations by the University of Valencia.