Using fibroblasts not stem cells as starter cells to grow vessels in the lab maintains characteristics of ageing
Old pipes become brittle and leaky, in both your bathroom and body. As we age, our blood vessels gradually thicken and stiffen, contributing to raised blood pressure, heart disease, and other conditions. Studying these changes is tricky, because extracting samples from patients is invasive, and creating fresh vessel cells from stem cells resets all the characteristics of ageing. A recent study uses a new trick to transform fibroblasts – common cells of the connective tissue – into vessel endothelial cells, which line blood vessels (pictured, white), and smooth muscle cells (red), which surround them. This direct reprogramming maintains the molecular markers of age, so by using donor cells from young and old volunteers, the researchers could compare the nature of the vessels at different ages. They discovered genes involved in inflammation and calcification active at different ages, and even tested a promising potential treatment to prevent leakage in older vessels.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.