Medical Research Council - London Institute of Medical Sciences

Now in our 9th year of bringing you beautiful imagery from biomedical science every day

Banking on Organoids

Building a bank of tumour models for the diversity of childhood kidney cancers

09 May 2020

Banking on Organoids

Cancers are diverse, even at the level of a single organ such as the kidney. The kidney has over 30 different cell types which can become involved in tumour development. Different kidney cancer types involve different combinations of cells. Better models of these tumours are needed to reflect their diversity for more informative research. Researchers now describe the first children’s cancer organoid biobank, which includes kidney cancer organoids from over 50 children with different cancer types. These organoids were grown from tumour samples from patients and retained key features of the original tumours. Using high-resolution 3D imaging, researchers demonstrated that an organoid from a kidney cancer type called Wilms' tumour (pictured) contained multiple cell types — epithelial (red), blastemal (green) and stromal cells (white) — that accurately reflected Wilms' tumours in patients. This showcases how the biobank can provide faithful models to investigate tumour biology and test cancer drugs.

Written by Lux Fatimathas

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.