Lab-grown liver tissue without use of animal-derived factors unsuitable for human transplant
With hundreds of people waiting for a liver transplant in the UK, researchers are working towards developing an alternative to donor transplants — lab-grown liver tissues or organoids. There's already been success growing liver organoids in specially designed environments called matrices. However, these matrices are made using animal components, making them unsuitable for use in human transplants. Researchers now show how a non-animal matrix made using a specific blend of chemicals is just as successful in growing liver organoids, as revealed by fluorescent microscopy (pictured). The liver markers present in organoids grown using the non-animal matrix (bottom) were comparable to those grown using the animal matrix (top). This brings us a step closer to growing liver tissues for transplantations.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.