Skin and sensory cells collaborate in embryonic development
In the first days of life, embryonic cells shuffle into place. This morphogenesis shapes our early tissues, but also requires careful coordination. Seeking insights, scientists turn to genetically similar, but easier to study, organisms like this zebrafish. Cells in its posterior lateral line primordium PLLp, (highlighted in green) usually migrate along the fish, peppering its body with tiny sensory organs. But this zebrafish is wounded – its skin (purple) is torn. Only when the skin heals (later in the video) does the PLLp continue to migrate. Researchers used a high-powered 3D imaging technique to capture clues to a cellular collaboration between skin and PLLp, which helps to knit early tissues into place. They now hope to follow other developmental milestones and link them to similar communicating tissues in human development.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.