New roles discovered for growth factor called Pyramus in development
Like you drop a note through a neighbour’s letterbox, cells send messages to nearby companions, with instructions like ‘move’ or ‘die’ (hopefully not quite what you suggest to neighbours). To better understand the fundamentals of these widespread and crucial interactions, researchers investigated how just one of these messages, or ligands, is able to relay many messages in the simple fruit fly. They found multiple components, including a tether preventing the message spreading too far from the sender, like two cups on a string, and one that controls the volume of the message, helping distinguish an urgent shout from a gentle suggestion. These subtleties enable clear communication, and the ligand in question – FGF Pyramus, red in the developing fly embryo sequence pictured, with corresponding receptors in green – is key to healthy heart development in both flies and humans. Deciphering its methods of communication could reveal clues to preventing developmental heart defects.
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