Medical Research Council - London Institute of Medical Sciences

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Keep it Tight

Visualising chromatin – the proteins that package DNA – to distinguish between healthy and cancerous cells

30 March 2022

Keep it Tight

As soon as one or two threads in a ball of string come loose, the whole structure can fall apart, leaving a tangled, impractical mess. Long strands of DNA in our cells are wrapped tightly around proteins in a combined structure called chromatin and, like the tangle in the back of your craft drawer, are problematic when they lose their shape. Disrupted chromatin is a hallmark of cancer, but until now how the structure changes has been unclear. A new approach to visualising the transformation has given researchers an unprecedented look at the process. A fluorescent dye binds to DNA, and the dense arrangement of healthy tight chromatin structure shines more brightly than unfurling sections. Clear differences were seen between healthy, precancerous (pictured) and cancerous cells. Tracking this change could help stratify the risk of patients, catching cancer early and guiding treatment.

Written by Anthony Lewis

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