BPoD has moved!

BPoD has recently changed our domain name - we can now be found at bpod.org.uk

Please update your bookmarks!

Now in our 13th year of bringing you beautiful imagery from biomedical science every day

Search the archive of over 4000 images

Mystery in Miniature

Renal organoids – lab-grown 'mini kidneys' – enables study of genetic disorder tuberous sclerosis and of drugs to treat it

02 August 2022

Mystery in Miniature

A rare genetic condition, tuberous sclerosis complex (TSC) causes the development of cysts and benign tumours in the kidneys and other organs, with potentially life-threatening consequences. While we know TSC is caused by mutations in the genes TSC1 or TSC2, the actual cellular processes affected have remained something of an enigma. In a recent breakthrough, researchers were able to investigate the effects of mutations in these genes using renal organoids, miniature self-organised clusters of cells that recapitulate the structures and functions of kidneys (pictured, with various kidney structures highlighted in different colours). When tracking the development of organoids made from cells lacking functional TSC1 or TSC2 they found disruptions to the developmental pathways of multiple cell types, contributing to the puzzling diversity of tumours associated with TSC. While there is currently no cure for TSC, these organoids could also prove a useful tool for testing potential drugs in the future.

Written by Emmanuelle Briolat

Search The Archive

Submit An Image

Follow on Tumblr

Follow on Instagram

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.