tag:bpod.org.uk,2005:/feed?domain_redirected=trueBPoD - Biomedical Picture of the Day2024-03-19T00:00:00+00:00tag:bpod.org.uk,2005:Picture/56392024-03-19T00:00:00+00:002024-03-19T00:00:00+00:00Emulating Embryos<img alt="Emulating Embryos" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5639/profile/BPoD-Emulating_Embros_19.3.24.jpg?1710429762" /><p>A <a href="https://en.wikipedia.org/wiki/Retinoic_acid"target="_blank">retinoic acid</a> treatment regimen induces 3D structures of lab-grown <a href="https://en.wikipedia.org/wiki/Embryonic_stem_cell"target="_blank">human embryonic stem cells</a> (<a href="https://en.wikipedia.org/wiki/Gastruloid"target="_blank">gastruloids</a>) to reliably organise into embryo-like structures, including a <a href="https://en.wikipedia.org/wiki/Neural_tube"target="_blank">neural tube</a> (the start of the central nervous system) and <a href="https://en.wikipedia.org/wiki/Somite"target="_blank">segmented somites</a></p>
<p>Read the published research article <a href="https://doi.org/10.1101/2024.02.10.579769"target="_blank">here</a></p><ul>
<li><a title="https://shendure-web.gs.washington.edu/alumni.html" target="_blank" href="https://shendure-web.gs.washington.edu/alumni.html">Image from work by Nobuhiko Hamazaki and Wei Yang, and colleagues</a></li>
<li><a title="Department of Genome Sciences, University of Washington, Seattle, WA, USA" target="_blank" href="https://www.gs.washington.edu/">Department of Genome Sciences, University of Washington, Seattle, WA, USA</a></li>
<li>Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)</li>
<li><a title="Published in bioRxiv, February 2024 (not peer reviewed)" target="_blank" href="https://doi.org/10.1101/2024.02.10.579769">Published in bioRxiv, February 2024 (not peer reviewed)</a></li>
</ul><img alt="Emulating Embryos" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5639/thumb/BPoD-Emulating_Embros_19.3.24.jpg?1710429762" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56382024-03-18T00:00:00+00:002024-03-18T00:00:00+00:00Lens in Focus<img alt="Lens in Focus" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5638/profile/BPoD-Lens_in_Focus_18.3.24.jpg?1710418301" />
<p>Protein called <a href="https://en.wikipedia.org/wiki/Fibroblast_growth_factor"target="_blank">fibroblast growth factor</a> underlies the signals shaping <a href="https://en.wikipedia.org/wiki/Lens_(vertebrate_anatomy)#Lens_fibers"target="_blank">fibres</a> in the developing eye <a href="https://en.wikipedia.org/wiki/Lens_(vertebrate_anatomy)"target="_blank">lens</a> as they grow to sculpt the lens into the correct shape for focussing light onto the <a href="https://en.wikipedia.org/wiki/Retina"target="_blank">retina</a></p>
<p>Read the published article <a href="https://doi.org/10.1242/dev.202123"target="_blank">here</a></p><ul>
<li><a title="https://www.sydney.edu.au/save-sight-institute/" target="_blank" href="https://www.sydney.edu.au/save-sight-institute/">Image from work by Yuki Sugiyama and colleagues</a></li>
<li><a title="Developmental Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, Japan & Save Sight Institute, The University of Sydney, Sydney, NSW, Australia" target="_blank" href="https://www.oist.jp/research/research-units/dnu">Developmental Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, Japan & Save Sight Institute, The University of Sydney, Sydney, NSW, Australia</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in Development, February 2024" target="_blank" href="https://doi.org/10.1242/dev.202123">Published in Development, February 2024</a></li>
</ul><img alt="Lens in Focus" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5638/thumb/BPoD-Lens_in_Focus_18.3.24.jpg?1710418301" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56422024-03-17T00:00:00+00:002024-03-17T00:00:00+00:00Mutant Gene Model <img alt="Mutant Gene Model " src="//s3.amazonaws.com/mrc-bpod-production/imgs/5642/profile/BPoD-Mutant_Gene_Model_17.3.24.jpg?1710428535" /><p>Zebrafish with a mutation in a gene called <em><a href="https://en.wikipedia.org/wiki/FOXE1"target="_blank">FOXE1</a></em> show <a href="https://en.wikipedia.org/wiki/Hypothyroidism"target="_blank">hypothyroidism</a> and cranio-facial abnormalities, features of the human genetic disorder <a href="https://en.wikipedia.org/wiki/Bamforth%E2%80%93Lazarus_syndrome"target="_blank">Bamforth-Lazarus syndrome</a></p><p>Read the published research article <a href="https://doi.org/10.1101/2024.01.31.578204"target="_blank">here</a></p> <ul>
<li>Image from work by Sophie T Raterman and colleagues</li>
<li><a title="Department of Dentistry-Orthodontics and Craniofacial Biology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, Netherlands" target="_blank" href="https://www.ru.nl/en/departments/dentistry/orthodontics-and-craniofacial-biology">Department of Dentistry-Orthodontics and Craniofacial Biology, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, Netherlands</a></li>
<li>Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)</li>
<li><a title="Published in bioRxiv, February 2024 (not peer reviewed)" target="_blank" href="https://doi.org/10.1101/2024.01.31.578204">Published in bioRxiv, February 2024 (not peer reviewed)</a></li>
</ul><img alt="Mutant Gene Model " class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5642/thumb/BPoD-Mutant_Gene_Model_17.3.24.jpg?1710428535" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56352024-03-16T00:00:00+00:002024-03-16T00:00:00+00:00From the Heart<img alt="From the Heart" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5635/profile/BPoD-From_the_Heart_16.3.24.jpg?1710413355" /><p>Study of a <a href="https://bpod.org.uk/archive/2012/3/25"target="_blank">zebrafish model</a> provides direct evidence that <a href="https://en.wikipedia.org/wiki/Haematopoiesis"target="_blank">blood cells</a> – mainly <a href="https://en.wikipedia.org/wiki/Neutrophil"target="_blank">neutrophils</a> – are produced in developing embryos by the tissue lining the heart (<a href="https://en.wikipedia.org/wiki/Endocardium"target="_blank">endocardium</a>) and reveals the molecular signals that regulate this</p><p>Read the published research article <a href="https://doi.org/10.1016/j.celrep.2024.113736"target="_blank">here</a></p> <ul>
<li><a title="https://health.usf.edu/medicine/labs/sumanas-lab" target="_blank" href="https://health.usf.edu/medicine/labs/sumanas-lab">Video from work by Suman Gurung, Nicole K. Restrepo and Saulius Sumanas</a></li>
<li><a title="Department of Pathology and Cell Biology, USF Health Heart Institute, University of South Florida, Tampa, FL, USA" target="_blank" href="https://health.usf.edu/medicine/pcb/">Department of Pathology and Cell Biology, USF Health Heart Institute, University of South Florida, Tampa, FL, USA</a></li>
<li>Video originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)</li>
<li><a title="Published in Cell Reports, February 2024" target="_blank" href="https://doi.org/10.1016/j.celrep.2024.113736">Published in Cell Reports, February 2024</a></li>
</ul><img alt="From the Heart" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5635/thumb/BPoD-From_the_Heart_16.3.24.jpg?1710413355" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56342024-03-15T00:00:00+00:002024-03-15T00:00:00+00:00Vital for Immunity<img alt="Vital for Immunity" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5634/profile/BPoD-Vital_for_Immunity_15.3.24.jpg?1710244962" /><p>Importance of <a href="https://en.wikipedia.org/wiki/Peroxisome"target="_blank">peroxisomes</a> – organelles inside cells that are involved in lipid metabolism – for immune cell development and immune responses revealed by defects seen in a peroxisome-deficient mouse model of the congenital disorder <a href="https://en.wikipedia.org/wiki/Zellweger_syndrome"target="_blank">Zellweger disease</a></p>
<p>Read the published research article <a href="https://doi.org/10.1016/j.celrep.2024.113744"target="_blank">here</a></p><ul>
<li><a title="https://dicara.wixsite.com/dicaralab" target="_blank" href="https://dicara.wixsite.com/dicaralab">Image from work by Brendon D. Parsons and Daniel Medina-Luna, and colleagues</a></li>
<li><a title="University of Alberta, Department of Laboratory Medicine and Pathology, Edmonton, AB, Canada" target="_blank" href="https://www.ualberta.ca/laboratory-medicine-and-pathology/index.html">University of Alberta, Department of Laboratory Medicine and Pathology, Edmonton, AB, Canada</a></li>
<li>Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)</li>
<li><a title="Published in Cell Reports, February 2024" target="_blank" href="https://doi.org/10.1016/j.celrep.2024.113744">Published in Cell Reports, February 2024</a></li>
</ul><img alt="Vital for Immunity" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5634/thumb/BPoD-Vital_for_Immunity_15.3.24.jpg?1710244962" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56362024-03-14T00:00:00+00:002024-03-14T00:00:00+00:00Long Life Eggs<img alt="Long Life Eggs" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5636/profile/BPoD-Long-life_Eggs_14.3.24.jpg?1710242733" /><p><a href="https://en.wikipedia.org/wiki/Oocyte"target="_blank">Oocytes</a> [egg cells] – with a female mammal from birth – provide <a href="https://en.wikipedia.org/wiki/Cytoplasm"target="_blank">cytoplasm</a> for a resulting embryo so must be maintained in good condition over a long time. This study shows how potentially damaging protein aggregates are stored for degradation in 'compartments' (<a href="https://en.wikipedia.org/wiki/Vesicle_(biology_and_chemistry)"target="_blank">vesicle</a> assemblies) in the oocyte</p>
<p>Read the published research article <a href="https://doi.org/10.1016/j.cell.2024.01.031"target="_blank">here</a></p><ul>
<li><a title="https://www.crg.eu/en/elvan-boke" target="_blank" href="https://www.crg.eu/en/elvan-boke">Still from a video from work by Gabriele Zaffagnini and colleagues</a></li>
<li><a title="Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain" target="_blank" href="https://www.crg.eu/">Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY-NC 4.0)</li>
<li><a title="Published in Cell, February 2024" target="_blank" href="https://doi.org/10.1016/j.cell.2024.01.031">Published in Cell, February 2024</a></li>
</ul><img alt="Long Life Eggs" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5636/thumb/BPoD-Long-life_Eggs_14.3.24.jpg?1710242733" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56372024-03-13T00:00:00+00:002024-03-13T00:00:00+00:00Size in Sight<img alt="Size in Sight" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5637/profile/BPoD-Size_in_Sight_13.3.24.jpg?1710240954" />
<p>Two novel distinct types of <a href="https://en.wikipedia.org/wiki/Amacrine_cell"target="_blank">amacrine cells</a> – neurons that connect from the eye's light-sensitive <a href="https://en.wikipedia.org/wiki/Retina"target="_blank">retina</a> to the brain – identified in zebrafish that respond differently to different sized moving objects</p>
<p>Read the published research article <a href="https://doi.org/10.1371/journal.pbio.3002506">here</a></p><ul>
<li>Image from work by Yan Li and colleagues</li>
<li><a title=" Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China" target="_blank" href="http://english.cebsit.cas.cn/"> Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in PLOS Biology, February 2024" target="_blank" href="https://doi.org/10.1371/journal.pbio.3002506">Published in PLOS Biology, February 2024</a></li>
</ul><img alt="Size in Sight" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5637/thumb/BPoD-Size_in_Sight_13.3.24.jpg?1710240954" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56332024-03-12T00:00:00+00:002024-03-12T00:00:00+00:00Centriole Formation<img alt="Centriole Formation" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5633/profile/BPoD-Structural_Role_12.3.24.jpg?1710159357" /><p>Protein called <strong>SAS-6</strong> role in the maintenance of the architecture of <a href="https://en.wikipedia.org/wiki/Centriole#"target="_blank">centrioles</a> – specialised structures involved in organising cell contents during <a href="https://en.wikipedia.org/wiki/Cell_division"target="_blank">division</a> – as they form early in embryonic development in cells that generate mouse <a href="https://en.wikipedia.org/wiki/Embryonic_stem_cell"target="_blank">embryonic stem cells</a> </p>
<p>Read the published article <a href="https://doi.org/10.7554/eLife.94694"target="_blank">here</a></p><ul>
<li><a title="https://bazzilab.com/" target="_blank" href="https://bazzilab.com/">Image from work by Marta Grzonka and Hisham Bazzi</a></li>
<li><a title="Department of Cell Biology of the Skin and Department of Dermatology and Venereology, Medical Faculty, University of Cologne, Cologne, Germany" target="_blank" href="https://portal.uni-koeln.de/en/uoc-home">Department of Cell Biology of the Skin and Department of Dermatology and Venereology, Medical Faculty, University of Cologne, Cologne, Germany</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in eLife, February 2024" target="_blank" href="https://doi.org/10.7554/eLife.94694">Published in eLife, February 2024</a></li>
</ul><img alt="Centriole Formation" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5633/thumb/BPoD-Structural_Role_12.3.24.jpg?1710159357" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56282024-03-11T00:00:00+00:002024-03-11T00:00:00+00:00Zika Flies<img alt="Zika Flies" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5628/profile/BPoD-Zika_Flies_11.3.24.jpg?1709722211" />
<p><a href="https://bpod.org.uk/archive/2012/4/10"target="_blank">Fruit flies</a> bearing <a href="https://en.wikipedia.org/wiki/Zika_fever"target="_blank">Zika virus </a> proteins as a live model for studying the mechanisms underlying infection in humans with <a href="https://en.wikipedia.org/wiki/Zika_fever"target="_blank">Zika virus </a>and how it causes <a href="https://en.wikipedia.org/wiki/Zika_fever#Microcephaly"target="_blank">microcephaly</a></p>
<p>Read the published article <a href="https://doi.org/10.1242/dmm.050297"target="_blank">here</a></p><ul>
<li><a title="https://linkneurolab.org/" target="_blank" href="https://linkneurolab.org/">Image from work by Nichole Link and J. Michael Harnish, and colleagues</a></li>
<li><a title="Department of Neurobiology, University of Utah, Salt Lake City, UT and Department of Molecular and Human Genetics, BCM, Houston, TX, USA " target="_blank" href="https://www.yamamotoflylab.org/">Department of Neurobiology, University of Utah, Salt Lake City, UT and Department of Molecular and Human Genetics, BCM, Houston, TX, USA </a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in and on the cover of Disease Models & Mechanisms, February 2024" target="_blank" href="https://doi.org/10.1242/dmm.050297">Published in and on the cover of Disease Models & Mechanisms, February 2024</a></li>
</ul><img alt="Zika Flies" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5628/thumb/BPoD-Zika_Flies_11.3.24.jpg?1709722211" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56322024-03-10T00:00:00+00:002024-03-10T00:00:00+00:00Malignant Memoir<img alt="Malignant Memoir" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5632/profile/BPoD-Malignant_Memoir_10.3.24.jpg?1709722068" /><p>Using single-cell and spatial (across the tumour tissue landscape) <a href="https://en.wikipedia.org/wiki/Multiomics"target="_blank">multi-omics</a> (including profiling the <a href="https://en.wikipedia.org/wiki/Genomics"target="_blank">genome</a> and <a href="https://en.wikipedia.org/wiki/Transcriptomics_technologies"target="_blank">gene activity</a>) – to map the evolution of <a href="https://en.wikipedia.org/wiki/Colorectal_cancer">colorectal cancer </a>and its <a href="https://en.wikipedia.org/wiki/Tumor_microenvironment"target="_blank"target="_blank">microenvironment</a> simultaneously as the disease progresses. Insight for stratifying disease type and treatments</p>
<p>Read the published research article <a href="https://doi.org/10.1016/j.cell.2023.11.006"target="_blank">here</a></p><ul>
<li><a title="https://kenlaulab.org/" target="_blank" href="https://kenlaulab.org/">Image from work by Cody N. Heiser and colleagues</a></li>
<li><a title="Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA" target="_blank" href="https://medschool.vanderbilt.edu/cpb/">Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA</a></li>
<li>Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)</li>
<li><a title="Published in Cell, December 2023" target="_blank" href="https://doi.org/10.1016/j.cell.2023.11.006">Published in Cell, December 2023</a></li>
</ul><img alt="Malignant Memoir" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5632/thumb/BPoD-Malignant_Memoir_10.3.24.jpg?1709722068" />The BPOD Team