Biologists strive to understand life, but often they find themselves swamped with information. Studies of how genes switch on or off, known as gene expression, sometimes examine hundreds of genes at once, inside millions of single cells – useful information, but a headache to interpret. A new set of software, called Scanpy, applies automated analysis to these mountains of data. Looking like impressionist art, 1.3 million mouse brain cells are grouped or 'clustered' into colours and locations on this chart. Each cluster might correspond to changes in a different gene, or a relationship between different cells. But it’s not all about producing pretty graphs – patterns in this cloud of numbers may give clues to treating diseases, and Scanpy allows computers to learn to spot them. Machine learning algorithms can be plugged in to take the pressure of biologists surrounded by life’s complexity.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.