Medical Research Council - London Institute of Medical Sciences

Now in our 11th year of bringing you beautiful imagery from biomedical science every day

Help for Helpers

Applying the anti-skin cancer drug imiquimod at a vaccine site boosts response

19 May 2020

Help for Helpers

As sadly revealed by the coronavirus pandemic, reduced immunity makes elderly people more vulnerable to infectious diseases, but it also means they respond less strongly to vaccines. Following vaccination, dendritic cells that have encountered a foreign antigen [molecule from the pathogen] travel to our lymph nodes, where they activate antibody-producing B cells to multiply in germinal centres , with assistance from T helper cells. In older lymph nodes, reduced stimulation from dendritic cells after vaccination leads to the formation of fewer of these essential T cells (pictured, in green, in lymph nodes from young (top) and old mice (below)), generating a weaker response overall. Yet researchers found a way to overcome these defects in immune activity, by applying the drug imiquimod at the vaccination site. Currently used in creams to treat genital warts and some skin cancers, imiquimod boosted T cell numbers in older mice, raising the possibility that age-related declines in immunity can be corrected.

Written by Emmanuelle Briolat

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at with translations by the University of Valencia.