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Help for Helpers

Applying the anti-skin cancer drug imiquimod at a vaccine site boosts response

19 May 2020

Help for Helpers

As sadly revealed by the coronavirus pandemic, reduced immunity makes elderly people more vulnerable to infectious diseases, but it also means they respond less strongly to vaccines. Following vaccination, dendritic cells that have encountered a foreign antigen [molecule from the pathogen] travel to our lymph nodes, where they activate antibody-producing B cells to multiply in germinal centres , with assistance from T helper cells. In older lymph nodes, reduced stimulation from dendritic cells after vaccination leads to the formation of fewer of these essential T cells (pictured, in green, in lymph nodes from young (top) and old mice (below)), generating a weaker response overall. Yet researchers found a way to overcome these defects in immune activity, by applying the drug imiquimod at the vaccination site. Currently used in creams to treat genital warts and some skin cancers, imiquimod boosted T cell numbers in older mice, raising the possibility that age-related declines in immunity can be corrected.

Written by Emmanuelle Briolat

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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