Medical Research Council - London Institute of Medical Sciences

Now in our 12th year of bringing you beautiful imagery from biomedical science every day

Mammary Makers

Modelling the communication between mammary blood vessel and duct cells important in development and disease

26 July 2020

Mammary Makers

While mammary ducts are essential to developing breast tissue and milk production, they are also prone to genetic mutations which may lead to cancer. To investigate, scientists grew these 'model' ducts (highlighted in turquoise) from human mammary cells in the lab, while also recreating their microenvironment of nearby blood vessels (in green with blue nuclei). The middle and right ducts developed from healthy cells mixed with cells harbouring mutations in important genes – with drastic effects on their development and shape compared to the healthy duct (left). Surprisingly, chemicals produced by the mutated ducts affect cells in nearby vessels, leaving them weakened and 'leaky'. Such biology-mimicking models continue to offer perspectives on cancer that may be difficult to investigate in living tissues, and future studies may suggest how chemical messages between these tissues, an example of paracrine signalling, may be switched on or off during development or disease.

Written by John Ankers

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at with translations by the University of Valencia.