Medical Research Council - London Institute of Medical Sciences

Now in our 10th year of bringing you beautiful imagery from biomedical science every day

Early Detection

Monkey model that mimics human Alzheimer's disease progression

29 May 2021

Early Detection

We often read about scientific discoveries that could in future lead to new treatments for incurable diseases – but how long, if successful, will that process take? To improve how well fundamental research translates from the lab to the clinic, neuroscientists developed a way of mimicking in rhesus macaque monkeys the early stages of Alzheimer’s disease, a neurodegenerative disease whose initial brain lesions can spread unnoticed for years before irreversible damage has been done and memory loss starts. Here, toxic tau proteins that accumulate in the brain of Alzheimer’s patients were visible in the macaque brain (orange) at early stages of disease progression. With this animal model that closely resembles human physiology, the team will be able to better understand the early-stage disease changes that take place in the brain, and potentially discover new insights on how damage can be slowed or reversed before the first cognitive symptoms manifest.

Written by Gaëlle Coullon

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.