Cells with distinct pathways of signals identified by 'barcodes' derived from molecular activity
Here, we see dozens of human skin cancer cells with their nuclei stained red. Each cell has been genetically engineered to make one of four fluorescent proteins – blue, cyan, green, or yellow – restricted to one of three areas. This combination of colour and space gives each cell one of 12 different 'barcodes', which researchers can use to tell them apart. Being able to recognise and test different types of living cells allows biologists to answer lots of interesting questions. Calling it the Signalome, the scientists have used their technique to study 12 different cancer signalling pathways at the same time. Their results show that hundreds of different cancer drugs ultimately upset the balance between cell growth and division. This insight could inform how we design new cancer treatments. The team plan to expand the Signalome to include hundreds of barcodes to help better understand complex cell behaviours.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.