tag:bpod.org.uk,2005:/feed?domain_redirected=trueBPoD - Biomedical Picture of the Day2024-03-28T00:00:00+00:00tag:bpod.org.uk,2005:Picture/56472024-03-28T00:00:00+00:002024-03-28T00:00:00+00:00Neuronly Connect <img alt="Neuronly Connect " src="//s3.amazonaws.com/mrc-bpod-production/imgs/5647/profile/BPoD-Neuronly_Connect_28.3.24.jpg?1711366861" /><p>'Flying' along neurites (projections that connect <a href="https://en.wikipedia.org/wiki/Neuron"target="_blank">neurons</a> to others) using an AI-based self-steering system called <strong>RoboEM</strong> in <a href="https://en.wikipedia.org/wiki/Scanning_electron_microscope#3D_in_SEM"target="_blank">3D electron microscopy</a> data derived from mouse and human brain samples can replace human annotation input in complex <a href="https://en.wikipedia.org/wiki/Connectome"target="_blank">connectome </a>analyses</p>
<p>Read the published research article <a href="https://doi.org/10.1038/s41592-024-02226-5"target="_blank">here</a></p><ul>
<li>Video adapted from work by Martin Schmidt and colleagues </li>
<li><a title="Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany" target="_blank" href="https://brain.mpg.de/helmstaedter">Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany</a></li>
<li>Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in Nature Methods, March 2024" target="_blank" href="https://doi.org/10.1038/s41592-024-02226-5">Published in Nature Methods, March 2024</a></li>
</ul><img alt="Neuronly Connect " class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5647/thumb/BPoD-Neuronly_Connect_28.3.24.jpg?1711366861" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56462024-03-27T00:00:00+00:002024-03-27T00:00:00+00:00Colon Cancer Colony <img alt="Colon Cancer Colony " src="//s3.amazonaws.com/mrc-bpod-production/imgs/5646/profile/BPoD-Colon_Cancer_Colony_27.3.24.jpg?1711366806" /><p>A distinct group of <em><a href="https://en.wikipedia.org/wiki/Fusobacterium_nucleatum"target="_blank">Fusobacterium nucleatum</a></em> bacteria, <a href="https://en.wikipedia.org/wiki/Microbiome"target="_blank">microbiome</a> resident of the mouth but uncommon in the normal lower gut, is predominant in human <a href="https://en.wikipedia.org/wiki/Colorectal_cancer"target="_blank">colorectal cancers</a></p>
<p>Read the published research article <a href="https://doi.org/10.1038/s41586-024-07182-w"target="_blank">here</a></p><ul>
<li>Image from work by Martha Zepeda-Rivera and colleagues</li>
<li><a title="Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA" target="_blank" href="https://www.fredhutch.org/en/research/divisions/vaccine-infectious-disease-division.html">Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in Nature, March 2024" target="_blank" href="https://doi.org/10.1038/s41586-024-07182-w">Published in Nature, March 2024</a></li>
</ul><img alt="Colon Cancer Colony " class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5646/thumb/BPoD-Colon_Cancer_Colony_27.3.24.jpg?1711366806" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56482024-03-26T00:00:00+00:002024-03-26T00:00:00+00:00Delving in Detail<img alt="Delving in Detail" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5648/profile/BPoD-Delving_in_Detail_26.3.24.jpg?1711366723" /><p>Live imaging using <a href="https://en.wikipedia.org/wiki/Light_sheet_fluorescence_microscopy"target=_blank">light sheet microscopy</a> allows the depths of multicellular systems like <a href="https://en.wikipedia.org/wiki/Organoid"target="_blank">organoids</a> to be interrogated at the single cell level</p>
<p>Read the published research article <a href="https://doi.org/10.1038/s41592-024-02213-w"target="_blank">here</a></p><ul>
<li>Video from work by Franziska Moos & Simon Suppinger and colleagues</li>
<li><a title="Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland" target="_blank" href="https://www.fmi.ch/">Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland</a></li>
<li>Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in Nature Methods, March 2024" target="_blank" href="https://doi.org/10.1038/s41592-024-02213-w">Published in Nature Methods, March 2024</a></li>
</ul><img alt="Delving in Detail" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5648/thumb/BPoD-Delving_in_Detail_26.3.24.jpg?1711366723" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56442024-03-25T00:00:00+00:002024-03-25T00:00:00+00:00Details of Adhesion<img alt="Details of Adhesion" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5644/profile/BPoD-Details_of_Adhesion_25.3.24.jpg?1711107680" />
<p>Two additional <a href="https://en.wikipedia.org/wiki/Microfilament"target="_blank">actin filament</a> layers within <a href="https://en.wikipedia.org/wiki/Focal_adhesion"target="_blank">focal adhesions</a> – the points at which a cell's inner workings connect with the <a href="https://en.wikipedia.org/wiki/Extracellular_matrix"target="_blank">extracellular matrix</a> to regulate cell functions – discovered using a kind of <a href="https://en.wikipedia.org/wiki/Super-resolution_microscopy"target="_blank">super-resolution microscopy</a> called <strong>iPALM</strong></p>
<p>Read the published research article <a href="https://doi.org/10.1038/s41467-024-46868-7"target="_blank">here</a></p><ul>
<li>Image from work by Reena Kumari and colleagues</li>
<li><a title="HiLIFE Institute of Biotechnology, University of Helsinki, Helsinki, Finland" target="_blank" href="https://www.helsinki.fi/en/hilife-helsinki-institute-life-science/units/institute-biotechnology">HiLIFE Institute of Biotechnology, University of Helsinki, Helsinki, Finland</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in Nature Communications, March 2024" target="_blank" href="https://doi.org/10.1038/s41467-024-46868-7">Published in Nature Communications, March 2024</a></li>
</ul><img alt="Details of Adhesion" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5644/thumb/BPoD-Details_of_Adhesion_25.3.24.jpg?1711107680" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56452024-03-24T00:00:00+00:002024-03-24T00:00:00+00:00Malignant Evolution<img alt="Malignant Evolution" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5645/profile/BPoD-Malignant_Evolution_24.3.24.jpg?1711107576" /><p>Multi-pronged (<a href="https://en.wikipedia.org/wiki/Exome_sequencing"target="_blank">whole-exome sequencing</a>, <a href="https://en.wikipedia.org/wiki/RNA-Seq"target="_blank">RNA sequencing</a>, and <a href="https://en.wikipedia.org/wiki/Mass_cytometry"target="_blank">Imaging Mass Cytometry</a>) approach characterises at the single-cell level the heterogeneity of upper tract <a href="https://en.wikipedia.org/wiki/Transitional_cell_carcinoma"target="_blank">urothelial carcinoma</a> – cancers arising in the <a href="https://en.wikipedia.org/wiki/Ureter"target="_blank">ureter</a> and the <a href="https://en.wikipedia.org/wiki/Renal_pelvis"target="_blank">kidney's 'pelvis'</a> – from primary to metastatic</p>
<p>Read the published research article <a href="https://doi.org/10.1038/s41467-024-46320-w"target="_blank">here</a></p><ul>
<li>Image from work by Kentaro Ohara and colleagues</li>
<li><a title="Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA" target="_blank" href="https://pathology.weill.cornell.edu/">Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in Nature Communications, March 2024" target="_blank" href="https://doi.org/10.1038/s41467-024-46320-w">Published in Nature Communications, March 2024</a></li>
</ul><img alt="Malignant Evolution" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5645/thumb/BPoD-Malignant_Evolution_24.3.24.jpg?1711107576" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56292024-03-23T00:00:00+00:002024-03-23T00:00:00+00:00Placental Peep Hole<img alt="Placental Peep Hole" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5629/profile/BPoD-Placental_Peep_Hole_23.3.23.jpg?1711106703" /><p>An optical window implanted in the <a href="https://en.wikipedia.org/wiki/Placenta"target="_blank">placenta</a> of pregnant mice allows <a href="https://en.wikipedia.org/wiki/Photoacoustic_imaging"target="_blank">high-resolution photoacoustic</a> and <a href="https://en.wikipedia.org/wiki/Fluorescence_imaging"target="_blank">fluorescence imaging</a> of the placenta as it develops throughout pregnancy. A means to directly view function and failings</p>
<p>Read the published research article <a href="https://doi.org/10.1126/sciadv.adk1278"target=_blank">here</a></p>
<ul>
<li><a title="https://photoacoustics.pratt.duke.edu/" target="_blank" href="https://photoacoustics.pratt.duke.edu/">Image from work by Xiaoyi Zhu, Qiang Huang and Laiming Jiang, and colleagues</a></li>
<li><a title="Department of Biomedical Engineering, Duke University, Durham, NC, USA" target="_blank" href="https://bme.duke.edu/">Department of Biomedical Engineering, Duke University, Durham, NC, USA</a></li>
<li>Image contributed by Junjie Yao and published with a Creative Commons Attribution 4.0 International (CC BY-NC 4.0)</li>
<li><a title="Published in and on the cover of Science Advances, March 2024" target="_blank" href="https://doi.org/10.1126/sciadv.adk1278">Published in and on the cover of Science Advances, March 2024</a></li>
</ul><img alt="Placental Peep Hole" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5629/thumb/BPoD-Placental_Peep_Hole_23.3.23.jpg?1711106703" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56412024-03-22T00:00:00+00:002024-03-22T00:00:00+00:00Nervous System Shapers<img alt="Nervous System Shapers" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5641/profile/BPoD-Nervous_System_Shapers_22.3.24.jpg?1710496935" /></p>Identifying the genes that regulate the shaping and maintenance of the <a href="https://en.wikipedia.org/wiki/Drosophila_melanogaster"target="_blank">fruit fly</a> central nervous system – insight for possible roles for <a href="https://en.wikipedia.org/wiki/Sequence_homology"target="_blank">homologous</a> genes in mammals</p>
<p>Read the published research article <a href="https://doi.org/10.1101/2024.01.09.574922"target="_blank">here</a></p><ul>
<li><a title="https://sites.wustl.edu/skeathlab/" target="_blank" href="https://sites.wustl.edu/skeathlab/">Image from work by Haluk Lacin and Yuqing Zhu, and colleagues</a></li>
<li><a title="Division of Biological and Biomedical Systems, University of Missouri-Kansas City, Kansas City and Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA" target="_blank" href="https://med.umkc.edu/bms/">Division of Biological and Biomedical Systems, University of Missouri-Kansas City, Kansas City and Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY-NC 4.0)</li>
<li><a title="Published in bioRxiv, February 2024 (not peer reviewed)" target="_blank" href="https://doi.org/10.1101/2024.01.09.574922">Published in bioRxiv, February 2024 (not peer reviewed)</a></li>
</ul><img alt="Nervous System Shapers" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5641/thumb/BPoD-Nervous_System_Shapers_22.3.24.jpg?1710496935" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56402024-03-21T00:00:00+00:002024-03-21T00:00:00+00:00New Viewing Platform<img alt="New Viewing Platform" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5640/profile/BPoD-New_Viewing_Platform_21.3.24.jpg?1710495697" /><p>A new system that allows trans-scale optical imaging of large field of view and volume so that cells in whole organs and tissues can be mapped dynamically</p><p>Read the published research article <a href="https://doi.org/10.1101/2023.08.21.553997"target="_blank">here</a></p><ul>
<li><a title="https://www.sanken.osaka-u.ac.jp/labs/bse/" target="_blank" href="https://www.sanken.osaka-u.ac.jp/labs/bse/">Video from work by Taro Ichimura and colleagues</a></li>
<li><a title="Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan" target="_blank" href="https://transdimension.otri.osaka-u.ac.jp/e/index.html">Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in bioRxiv, February 2024 (not peer reviewed)" target="_blank" href="https://doi.org/10.1101/2023.08.21.553997">Published in bioRxiv, February 2024 (not peer reviewed)</a></li>
</ul><img alt="New Viewing Platform" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5640/thumb/BPoD-New_Viewing_Platform_21.3.24.jpg?1710495697" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56432024-03-20T00:00:00+00:002024-03-20T00:00:00+00:00All Together Now<img alt="All Together Now" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5643/profile/BPoD-All_Together_Now_20.3.24.jpg?1710497838" /><p>Profiling single cells within tissues according to the activity of multiple genes using methods called <strong><a href="https://en.wikipedia.org/wiki/Fluorescence_in_situ_hybridization"target="_blank">Fluorescence In Situ Hybridization</a> of Cellular HeterogeneIty and gene expression Programs (FISHnCHIPs)</strong> enables mapping of cell types within a tissue while preserving its architecture. Different cell types in a mouse whole brain section are shown in the image individually and as a composite</p>
<p>Read the published research article <a href="https://doi.org/10.1038/s41467-024-46669-y"target="_blank">here</a></p><ul>
<li>Adapted image from work by Xinrui Zhou and Wan Yi Seow, and colleagues</li>
<li><a title="Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore" target="_blank" href="https://www.a-star.edu.sg/gis">Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore</a></li>
<li>Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)</li>
<li><a title="Published in Nature Communications, March 2024" target="_blank" href="https://doi.org/10.1038/s41467-024-46669-y">Published in Nature Communications, March 2024</a></li>
</ul><img alt="All Together Now" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5643/thumb/BPoD-All_Together_Now_20.3.24.jpg?1710497838" />The BPOD Teamtag:bpod.org.uk,2005:Picture/56392024-03-19T00:00:00+00:002024-03-19T00:00:00+00:00Emulating Embryos<img alt="Emulating Embryos" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5639/profile/BPoD-Emulating_Embros_19.3.24.jpg?1710429762" /><p>A <a href="https://en.wikipedia.org/wiki/Retinoic_acid"target="_blank">retinoic acid</a> treatment regimen induces 3D structures of lab-grown <a href="https://en.wikipedia.org/wiki/Embryonic_stem_cell"target="_blank">human embryonic stem cells</a> (<a href="https://en.wikipedia.org/wiki/Gastruloid"target="_blank">gastruloids</a>) to reliably organise into embryo-like structures, including a <a href="https://en.wikipedia.org/wiki/Neural_tube"target="_blank">neural tube</a> (the start of the central nervous system) and <a href="https://en.wikipedia.org/wiki/Somite"target="_blank">segmented somites</a></p>
<p>Read the published research article <a href="https://doi.org/10.1101/2024.02.10.579769"target="_blank">here</a></p><ul>
<li><a title="https://shendure-web.gs.washington.edu/alumni.html" target="_blank" href="https://shendure-web.gs.washington.edu/alumni.html">Image from work by Nobuhiko Hamazaki and Wei Yang, and colleagues</a></li>
<li><a title="Department of Genome Sciences, University of Washington, Seattle, WA, USA" target="_blank" href="https://www.gs.washington.edu/">Department of Genome Sciences, University of Washington, Seattle, WA, USA</a></li>
<li>Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)</li>
<li><a title="Published in bioRxiv, February 2024 (not peer reviewed)" target="_blank" href="https://doi.org/10.1101/2024.02.10.579769">Published in bioRxiv, February 2024 (not peer reviewed)</a></li>
</ul><img alt="Emulating Embryos" class="image_thumb" src="//s3.amazonaws.com/mrc-bpod-production/imgs/5639/thumb/BPoD-Emulating_Embros_19.3.24.jpg?1710429762" />The BPOD Team